PROSER1 Modulates DNA Demethylation through Dual Mechanisms to Prevent Syndromic Developmental Malformations [RNA-seq]
DNA methylation · mouse · 12 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformationsGenes & development · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE273516_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA1142189 and SRA study SRP523252. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8430837 wildtype mESC RNA-seq biol rep 1 wildtype mESC RNA-seq b…
- GSM8430838 wildtype mESC RNA-seq biol rep 2 wildtype mESC RNA-seq b…
- GSM8430839 wildtype day2 in N2B27 RNA-seq biol rep 1 wildtype day2 in N2B27 …
- GSM8430840 wildtype day2 in N2B27 RNA-seq biol rep 2 wildtype day2 in N2B27 …
- GSM8430841 PROSER1 KO mESC RNA-seq biol rep 1 PROSER1 KO mESC RNA-seq…
- GSM8430842 PROSER1 KO mESC RNA-seq biol rep 2 PROSER1 KO mESC RNA-seq…
- GSM8430843 PROSER1 KO day2 in N2B27 RNA-seq biol rep 1 PROSER1 KO day2 in N2B2…
- GSM8430844 PROSER1 KO day2 in N2B27 RNA-seq biol rep 2 PROSER1 KO day2 in N2B2…
- GSM8430845 PROSER1 KO+Rescue mESC RNA-seq biol rep 1 PROSER1 KO+Rescue mESC …
- GSM8430846 PROSER1 KO+Rescue mESC RNA-seq biol rep 2 PROSER1 KO+Rescue mESC …
- GSM8430847 PROSER1 KO+Rescue day2 in N2B27 RNA-seq biol rep 1 PROSER1 KO+Rescue day2 …
- GSM8430848 PROSER1 KO+Rescue day2 in N2B27 RNA-seq biol rep 2 PROSER1 KO+Rescue day2 …
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.