GEO series
RNA-seq of ex vivo differentiated osteoclasts of FLT3 ITD Ptprc KO mice and controls
GSE273708
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2025/02/12
GPL24247
Summary
The receptor tyrosine kinase FLT3 is expressed in myeloid and lymphoid progenitor cells. Here, the influence of the FLT3 ITD mutation and PTPRC inactivation on the bone remodeling was studied in mice. Gene expression analysis of differentiated osteoclasts showed dysregulated signaling pathways influencing their differentiation as well as the coupling of bone resorption and formation.
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Paper (PMID 39906260) ↗
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