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NeuroD1-based in situ neural regeneration for the treatment of radiation-induced brain injury

GSE273938 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/07/22 Platform GPL24247
Summary
We aimed to study the therapeutic effects of in situ neural regeneration technology in radiation-induced brain injury (RIBI). We overexpressed the neural transcription factor NeuroD1 in the astrocytes of the injured area using an adeno-associated virus (AAV) in a RIBI mouse model. The therapeutic effects were compared with a RIBI mouse model treated with a control virus. Subsequently, we explored the therapeutic effect in transcriptome through a bulk RNA sequencing.
Published in
NeuroD1-based in situ neural regeneration for the treatment of radiation-induced brain injury
Yan X, Zhong K, Zhou M et al. · Neural regeneration research 2026 · PMID 41914076 · doi:10.4103/NRR.NRR-D-24-01067
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Also filed as BioProject PRJNA1144128 and SRA study SRP524123. Searching any of these in the dataset finder brings you back here.

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