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B cell receptor sequences from germinal center (-like) B cells and plasmablasts from inflamed lung and lung-draining lymph node

GSE274347 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/04/07 Platform GPL16417
Summary
Germinal center (GC) like B cells can be generated in unstructured non-ectopic T and B cell infiltrates in the in inflamed lung. We used heavy chain B cell receptor (BCR) RNA sequencing to compare antigen-specific B cells from lung to those from the lung-draining lymph node.
Published in
Activation and maturation of antigen-specific B cells in nonectopic lung infiltrates are independent of germinal center reactions in the draining lymph node
Schacht SS, Graffunder J, Durek P et al. · Cellular & molecular immunology 2025 · PMID 40210692 · doi:10.1038/s41423-025-01285-8
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Also filed as BioProject PRJNA1146017 and SRA study SRP525112. Searching any of these in the dataset finder brings you back here.

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