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The hepatic overexpression of C2-AKT ameliorates obesity-induced insulin resistance

GSE274517 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/08/26 Platform GPL24247
Summary
Metabolic disorders, such as obesity and diabetes, have become increasingly prevalent worldwide, posing significant challenges to public health. Insulin resistance, a hallmark of these disorders, is characterized by an impaired response to insulin in target tissues, leading to dysregulated glucose and lipid metabolism. Although the pathogenesis of insulin resistance is complex and multifactorial, mounting evidence suggests that disrupted intracellular calcium (Ca2+) homeostasis plays a crucial role in its development. To elucidate the molecular mechanisms underlying the improved metabolic profiles in C2-AKT overexpression mice, we performed RNA-seq on liver tissues from both control and C2-AKT mice
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Also filed as BioProject PRJNA1146934 and SRA study SRP525695. Searching any of these in the dataset finder brings you back here.

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