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The receptor tyrosine kinase EphB2 promotes MASH fibrosis in mice.

GSE274897 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/01/31 Platform GPL24247
Summary
Metabolic dysfunction-associated steatohepatitis (MASH) is emerging as the leading cause for liver transplantation worldwide. MASH is chatacterized by hepatic lipid accumulation, inlammation and fibrosis which is associaed with worst outcome in patients sufferring from this pathology. Using the Gubra Amyln NASH (GAN) diet model of murine MASH, we showed that global deletion of Ephb2 in mice protect them from GAN diet-induced inlammation and fibrosis. EphB2 could be a potential therapeutic target for the treatment of MASH fibrosis.
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Also filed as BioProject PRJNA1148424 and SRA study SRP526580. Searching any of these in the dataset finder brings you back here.

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