← BioTransfer GEO Dataset Finder
GEO series

Lack of dystrophin disrupts fetal muscle stem cell polarity and commitment during secondary myogenesis

GSE274925 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/09/29 Platform GPL19057
Summary
No cure exists for Duchenne Muscular Dystrophy (DMD), a devastating and fatal muscle degenerative disease caused by a loss-of-function mutations to the DMD gene which encode the large cytoskeleton protein dystrophin. Conventionally, the disease is thought to manifest around 3-5 years of age when fragile myofibers become damaged from patient ambulation. However, we find that perturbation in fetal muscle stem cell (fMuSC) commitment and polarity occur during secondary myogenesis in the mdx mouse, a model of DMD. To study the cell state and the transcriptomic profileof mdx fMuSCs, we conducted single cell RNA-sequencing of myogenic cells derived from the limbs of E17.5 Pax7-nGFP embryos on the C57BL/10ScSnJ and mdx backgrounds.
Published in
Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis
Esper ME, Lin AYT, Bennett D et al. · Nature communications 2025 · PMID 41238533 · doi:10.1038/s41467-025-64999-3
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE274925_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1148479 and SRA study SRP526631. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.