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Clonally expanded targetable natural killer-like T cells seed the aged spinal cord to disrupt wound healing

GSE275570 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/01/12 Platform GPL24247
Summary
CD8+ T cells that were found accumulated in the spinal cord preceding (aged) and following a spinal cord injury disrupt wound healing. We isolated spinal cord cells of the aged mice who were treated with IgG or anti-CD8 monoclonal antibody following spinal cord injury and transcriptionally profiled them by doing single cell RNAseq to identify what cells were affected after depleting CD8+ T cells.
Published in
Clonally expanded, targetable, natural killer-like NKG7 T cells seed the aged spinal cord to disrupt myeloid-dependent wound healing
Kong G, Song Y, Yan Y et al. · Neuron 2025 · PMID 39809279 · doi:10.1016/j.neuron.2024.12.012
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Also filed as BioProject PRJNA1151684 and SRA study SRP528325. Searching any of these in the dataset finder brings you back here.

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