SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq mice (genotype x timepoint)
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 16 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq-miceJournal of molecular and cellular cardiology plus · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276289_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1156561 and SRA study SRP530404. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 16 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8495107 WT 4 weeks 559480 NN
- GSM8495108 WT 4 weeks 559480 LN
- GSM8495109 WT 4 weeks 554815 NN
- GSM8495110 WT 4 weeks 554815 BN
- GSM8495111 Gαq 4 weeks 559480 RN
- GSM8495112 Gαq 4 weeks 559480 BN
- GSM8495113 Gαq 4 weeks 554815 RN
- GSM8495114 Gαq 4 weeks 554815 LN
- GSM8495115 WT 20 weeks 550660 NN
- GSM8495116 WT 20 weeks 444767 LN
- GSM8495117 WT 20 weeks 551636 RN
- GSM8495118 WT 20 weeks 551636 BN
- GSM8495119 Gαq 20 weeks 550660 LN
- GSM8495120 Gαq 20 weeks 550660 BN
- GSM8495121 Gαq 20 weeks 444767 NN
- GSM8495122 Gαq 20 weeks 444767 RN
- GSE268984 SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq mice (genotype x ERTU) 18 samples shares sglt2, phosphorylation, upregulates, myocardial, inhibitor, oxidative, genotype
- GSE276290 SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq mice 34 samples shares sglt2, phosphorylation, upregulates, myocardial, inhibitor, oxidative
- GSE270093 The SGLT2 Inhibitor Empagliflozin Enhances Metabolic Efficiency and Ameliorates Left Ventricular Hypertrophy in Myosin R403Q Mutant Hypertrophic Cardiomyopathy Mice 21 samples shares sglt2, inhibitor
- GSE293811 Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of lysine demethylation and oxidative phosphorylation [RNA-seq] 10 samples shares phosphorylation, oxidative
- GSE282799 IL-1 protects from fatal systemic candidiasis by inhibition of oxidative phosphorylation and hypoxia 10 samples shares phosphorylation, oxidative
- GSE248458 Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of lysine demethylation and oxidative phosphorylation 25 samples shares phosphorylation, oxidative
- GSE279174 Transcriptomics of SGLT2-positive early proximal tubule segments in mice: response to type 1 diabetes, SGLT1/2 inhibition or GLP1 receptor agonism 54 samples shares sglt2
- GSE307417 SGLT2 inhibition decreases complement C1q, maintaining renal antibacterial response 14 samples shares sglt2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.