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Single-nucleus transcriptome sequencing reveals a specific neuronal subtype in the arcuate nucleus.

GSE276414 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/12/10 Platform GPL28330
Summary
Over recent decades, research has established the hypothalamus, particularly the arcuate nucleus, as a central hub for the homeostatic control of energy balance. The hypothalamic arcuate nucleus is a pivotal regulator of energy balance, containing anorexic proopiomelanocortin (POMC) neurons and orexigenic agouti-related peptide (AgRP) neurons, which exert opposing effects on energy homeostasis. However, the molecular identity of “non-AgRP, non-POMC” neurons remains unclear. We identified a distinct neuronal subtype characterized by the absence of Agrp and Pomc expressions, while exhibiting robust Crabp1 expression.
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Also filed as BioProject PRJNA1157322 and SRA study SRP530638. Searching any of these in the dataset finder brings you back here.

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