HIF1α gates tendon response to overload and drives tendinopathy independently from vascular recruitment
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 8 × Mouse TTFs KO vs 8 × Mouse TTFs WTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitmentScience translational medicine · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276425_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1157332 and SRA study SRP530545. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 2 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8498385 Mouse TTFs KO 1 Mouse TTFs KO
- GSM8498386 Mouse TTFs KO 2 Mouse TTFs KO
- GSM8498387 Mouse TTFs WT 1 Mouse TTFs WT
- GSM8498388 Mouse TTFs WT 2 Mouse TTFs WT
- GSM8498389 Mouse TTFs KO 3 Mouse TTFs KO
- GSM8498390 Mouse TTFs WT 3 Mouse TTFs WT
- GSM8498391 Mouse TTFs WT 4 Mouse TTFs WT
- GSM8498392 Mouse TTFs WT 5 Mouse TTFs WT
- GSM8498393 Mouse TTFs WT 6 Mouse TTFs WT
- GSM8498394 Mouse TTFs KO 4 Mouse TTFs KO
- GSM8498395 Mouse TTFs KO 5 Mouse TTFs KO
- GSM8498396 Mouse TTFs WT 7 Mouse TTFs WT
- GSM8498397 Mouse TTFs WT 8 Mouse TTFs WT
- GSM8498398 Mouse TTFs KO 6 Mouse TTFs KO
- GSM8498399 Mouse TTFs KO 7 Mouse TTFs KO
- GSM8498400 Mouse TTFs KO 8 Mouse TTFs KO
- GSE296005 Chronic HIF1A activity in rod photoreceptors causes type 3 neovascularization and retinal atrophy 18 samples shares hif1, vascular
- GSE280375 Soluble αKlotho interacts with Hsp90aa1 to inhibit the chaperone machinery-mediated Hif1α stabilization and alleviate CKD-induced vascular calcification 12 samples shares hif1, vascular
- GSE252607 Cardiomyocyte specific RXFP1-overexpression protects Relaxin-independently from pressure-overload induced cardiac dysfunction 30 samples shares independently, overload
- GSE292517 AMPK signaling is dysregulated in human tendinopathy and loss of AMPKα1 leads to cell, matrix and mechanical dysfunction in mouse Achilles tendon [RNAseq_AMPK_WheelRunning] 25 samples shares tendinopathy, tendon
- GSE292357 AMPK signaling is dysregulated in human tendinopathy and loss of AMPKα1 leads to cell, matrix and mechanical dysfunction in mouse Achilles tendon 24 samples shares tendinopathy, tendon
- GSE317255 TERT drives liver tumorigenesis and immune reprogramming independently of telomere elongation 15 samples shares independently, drives
- GSE55698 Variant PRC1 complex dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation 41 samples shares recruitment, drives
- GSE282641 HIF1α Mediates Circadian Regulation of Skeletal Muscle Metabolism and Substrate Preference in Response to Time-of-Day Exercise 64 samples shares hif1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.