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mRNA sequencing after BMSC treatment of BDL-induced liver fibrosis

GSE276505 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/09/13 Platform GPL24247
Summary
Cholestatic liver disease (CLD) represents a severe pathological condition that can advance to cirrhosis and hepatocellular carcinoma. The activation of hepatic stellate cells (HSCs) is integral to the pathogenesis of CLD. Previous research has indicated that bone marrow mesenchymal stem cells (BMSCs) may offer therapeutic benefits for liver diseases. Nonetheless, the specific therapeutic efficacy and underlying mechanisms of BMSCs in the context of CLD remain inadequately understood. In this study, we aimed to elucidate the therapeutic efficacy and potential therapeutic genes of BMSCs transplantation in a murine model of cholangioligation-induced cholestatic liver fibrosis (CLF).
Published in
Bone mesenchymal stem cells attenuate hepatic stellate cell activation and liver fibrosis through REDD1/autophagy pathway
Huang T, Nie L, Diao H et al. · Stem cells translational medicine 2025 · PMID 40558385 · doi:10.1093/stcltm/szaf023
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Also filed as BioProject PRJNA1157746 and SRA study SRP530982. Searching any of these in the dataset finder brings you back here.

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