Fibroblast growth factor receptor signaling modulates cholesterol storage in a SOAT1-dependent manner to promote mammary tumor cell invasion
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Fibroblast growth factor receptor signaling modulates cholesterol storage in a SOAT1-dependent manner to promote mammary tumor cell invasionBreast cancer research : BCR · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276731_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1158773 and SRA study SRP531551. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8504633 HC11R1_12Q_BB_1st
- GSM8504634 HC11R1_12Q_BB_2nd
- GSM8504635 HC11R1_12Q_BB_3rd
- GSM8504636 HC11R1_12Q_EtOH_1st
- GSM8504637 HC11R1_12Q_EtOH_2nd
- GSM8504638 HC11R1_12Q_EtOH_3rd
- GSM8504639 HC11R1_19Q_BB_1st
- GSM8504640 HC11R1_19Q_BB_2nd
- GSM8504641 HC11R1_19Q_BB_3rd
- GSM8504642 HC11R1_19Q_EtOH_1st
- GSM8504643 HC11R1_19Q_EtOH_2nd
- GSM8504644 HC11R1_19Q_EtOH_3rd
- GSM8504645 HC11R1_Par_BB_1st
- GSM8504646 HC11R1_Par_BB_2nd
- GSM8504647 HC11R1_Par_BB_3rd
- GSM8504648 HC11R1_Par_EtOH_1st
- GSM8504649 HC11R1_Par_EtOH_2nd
- GSM8504650 HC11R1_Par_EtOH_3rd
- GSE336247 Cardiac fibroblast deletion of PTBP1 modulates the profibrotic response by alternative splicing II 36 samples shares fibroblast, modulates
- GSE271272 Fibroblast-derived osteoglycin promotes alveolar epithelial cell repair 32 samples shares fibroblast, promote
- GSE269634 Triggering AHR resolves TGF-β1 induced fibroblast activation and promotes AT1 cell regeneration in alveolar organoids 32 samples shares fibroblast, promote
- GSE272476 Neutrophils exposed to a cholesterol metabolite secrete extracellular vesicles that promote epithelial-mesenchymal transition and stemness in breast cancer cells [RNA-seq] 30 samples shares cholesterol, promote
- GSE306012 Temporal inhibition of ADAM17 in fibroblasts reduces stiffness and promotes vascularization following myocardial infarction 28 samples shares fibroblast, promote
- GSE273123 Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling (Bulk RNA-Seq) 16 samples shares fibroblast, promote
- GSE289751 Resolution of inflammation in imprinted fibroblast-like synoviocytes establishes a transcriptomic signature that promotes endothelial cell dysfunction. 12 samples shares fibroblast, promote
- GSE287133 Cardiac fibroblast deletion of PTBP1 modulates the profibrotic response by alternative splicing. 12 samples shares fibroblast, modulates
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.