SPT5 regulates RNA polymerase II stability via Cullin 3–ARMC5 recognition [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 33 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 33 samples: 33 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- SPT5 regulates RNA polymerase II stability via Cullin 3-ARMC5 recognitionScience advances · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277372_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1162054 and SRA study SRP533124. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 33 sample titles: 33 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8521187 ChIP-seq-01_Pol2_SPT5AID_shNT_H2O-3h
- GSM8521188 ChIP-seq-01_Pol2_SPT5AID_shNT_Aux-3h
- GSM8521189 ChIP-seq-01_Pol2_SPT5AID_shARMC5-1_H2O-3h
- GSM8521190 ChIP-seq-01_Pol2_SPT5AID_shARMC5-1_Aux-3h
- GSM8521191 ChIP-seq-01_Pol2_SPT5AID_shARMC5-2_H2O-3h
- GSM8521192 ChIP-seq-01_Pol2_SPT5AID_shARMC5-2_Aux-3h
- GSM8521193 ChIP-seq-01_Input_SPT5AID_shNT_H2O-3h
- GSM8521194 ChIP-seq-02_Pol2_SPT5AID_shNT_Aux-0m
- GSM8521195 ChIP-seq-02_Pol2_SPT5AID_shNT_Aux-90m
- GSM8521196 ChIP-seq-02_Pol2_SPT5AID_shNT_Aux-180m
- GSM8521197 ChIP-seq-02_Pol2_SPT5AID_shARMC5_Aux-0m
- GSM8521198 ChIP-seq-02_Pol2_SPT5AID_shARMC5_Aux-90m
- GSM8521199 ChIP-seq-02_Pol2_SPT5AID_shARMC5_Aux-180m
- GSM8521200 ChIP-seq-03_GFP_ARMC5-GFP-FL_SPT5-AID_H2O-90m_rep1
- GSM8521201 ChIP-seq-03_GFP_ARMC5-GFP-FL_SPT5-AID_Aux-90m_rep1
- GSM8521202 ChIP-seq-03_GFP_ARMC5-GFP-dB_SPT5-AID_H2O-90m_rep1
- GSM8521203 ChIP-seq-03_GFP_ARMC5-GFP-dB_SPT5-AID_Aux-90m_rep1
- GSM8521204 ChIP-seq-03_GFP_noGFP_SPT5-AID_H2O-90m_rep1
- GSM8521205 ChIP-seq-03_GFP_noGFP_SPT5-AID_Aux-90m_rep1
- GSM8521206 ChIP-seq-04_GFP_ARMC5-GFP-FL_SPT5-AID_H2O-90m_rep2
- GSM8521207 ChIP-seq-04_GFP_ARMC5-GFP-FL_SPT5-AID_Aux-90m_rep2
- GSM8521208 ChIP-seq-04_GFP_ARMC5-GFP-dB_SPT5-AID_H2O-90m_rep2
- GSM8521209 ChIP-seq-04_GFP_ARMC5-GFP-dB_SPT5-AID_Aux-90m_rep2
- GSM8521210 ChIP-seq-04_GFP_noGFP_SPT5-AID_H2O-90m_rep2
- GSM8521211 ChIP-seq-04_GFP_noGFP_SPT5-AID_Aux-90m_rep2
- GSM8521212 ChIP-seq-05_GFP_ARMC5-GFP-FL_SPT5-AID_DMSO_rep1
- GSM8521213 ChIP-seq-05_GFP_ARMC5-GFP-FL_SPT5-AID_NVP2_rep1
- GSM8521214 ChIP-seq-05_GFP_ARMC5-GFP-FL_SPT5-AID_Aux_rep1
- GSM8521215 ChIP-seq-05_GFP_ARMC5-GFP-FL_SPT5-AID_NVP2-Aux_rep1
- GSM8521216 ChIP-seq-06_GFP_ARMC5-GFP-FL_SPT5-AID_DMSO_rep2
- GSM8521217 ChIP-seq-06_GFP_ARMC5-GFP-FL_SPT5-AID_NVP2_rep2
- GSM8521218 ChIP-seq-06_GFP_ARMC5-GFP-FL_SPT5-AID_Aux_rep2
- GSM8521219 ChIP-seq-06_GFP_ARMC5-GFP-FL_SPT5-AID_NVP2-Aux_rep2
- GSE265881 Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II (ChIP-Seq) 72 samples shares spt5, polymerase, chip-seq
- GSE220316 Splicing Factor RBM22 Broadly Affects RNA Polymerase II 5' Pausing, Elongation Rate and Termination and Prevents Genome Instability [ChIP-seq] 64 samples shares polymerase, stability, chip-seq
- GSE265883 Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II (CUT&RUN) 68 samples shares spt5, polymerase
- GSE265884 Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II (RNA-Seq) 10 samples shares spt5, polymerase
- GSE292907 Selective CDK7 Inhibition Sensitizes Tumors to Topoisomerase I Inhibitor-Antibody Drug Conjugates by Blocking The Transition of The RNA polymerase II Initiation Complex into Elongation [ChIP-seq] 97 samples shares polymerase, chip-seq
- GSE202761 Receptor Tyrosine Kinases phosphorylate RNA polymerase II at signal-responsive genes [ChIP-seq] 64 samples shares polymerase, chip-seq
- GSE302076 The novel RNA polymerase I transcription inhibitor PMR-116 exploits a critical therapeutic vulnerability in a broad-spectrum of high MYC malignancies [ChIP-Seq] 45 samples shares polymerase, chip-seq
- GSE280548 The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release [ChIP-seq] 22 samples shares polymerase, chip-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.