GEO series
RNA sequencing of human monocyte-derived dendritic cells stimulated with CLEC10A ligand glycodendrimers in the presence of Pam3CysK4
GSE277565
Homo sapiens
Expression profiling by high throughput sequencing
24 samples
2025/11/01
GPL34284
Summary
To investigate ligand-specific responses via CLEC10A in human monocyte-derived dendritic cells, five CLEC10A ligands were coupled to dendrimers. The ligands consist of alfa-GalNAc and the GalNAc-containing structures Forssman antigen, blood group A antigen, asialo GM2, and GM2. The human dendritic cells of 4 independent donors were stimulated with these glycodendrimers or a control dendrimer (coupled to C6 chain) for 5 hours in the presence of TLR stimulus Pam3CysK4. Total RNA was isolated and sequenced.
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Paper (PMID 41241848) ↗
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