RNA-sequencing of inguinal white adipose tissue (iWAT) from kynurenine 3-monooxygenase (Kmo) knockout mice and wild-type littermates on chow and high-fat diets.
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × iWAT, wild-type, chow, vs 4 × iWAT, Kmo-KO, chow, vs 4 × iWAT, wild-type, HFD, vs 4 × iWAT, Kmo-KO, HFD,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Constitutive loss of kynurenine-3-monooxygenase changes circulating kynurenine metabolites without affecting systemic energy metabolismAmerican journal of physiology. Endocrinology and metabolism · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277692_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1163367 and SRA study SRP533889. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8527701 iWAT, wild-type, chow, rep1 iWAT, wild-type, chow,
- GSM8527702 iWAT, wild-type, chow, rep2 iWAT, wild-type, chow,
- GSM8527703 iWAT, wild-type, chow, rep3 iWAT, wild-type, chow,
- GSM8527704 iWAT, wild-type, chow, rep4 iWAT, wild-type, chow,
- GSM8527705 iWAT, Kmo-KO, chow, rep1 iWAT, Kmo-KO, chow,
- GSM8527706 iWAT, Kmo-KO, chow, rep2 iWAT, Kmo-KO, chow,
- GSM8527707 iWAT, Kmo-KO, chow, rep3 iWAT, Kmo-KO, chow,
- GSM8527708 iWAT, Kmo-KO, chow, rep4 iWAT, Kmo-KO, chow,
- GSM8527709 iWAT, wild-type, HFD, rep1 iWAT, wild-type, HFD,
- GSM8527710 iWAT, wild-type, HFD, rep2 iWAT, wild-type, HFD,
- GSM8527711 iWAT, wild-type, HFD, rep3 iWAT, wild-type, HFD,
- GSM8527712 iWAT, wild-type, HFD, rep4 iWAT, wild-type, HFD,
- GSM8527713 iWAT, Kmo-KO, HFD, rep1 iWAT, Kmo-KO, HFD,
- GSM8527714 iWAT, Kmo-KO, HFD, rep2 iWAT, Kmo-KO, HFD,
- GSM8527715 iWAT, Kmo-KO, HFD, rep3 iWAT, Kmo-KO, HFD,
- GSM8527716 iWAT, Kmo-KO, HFD, rep4 iWAT, Kmo-KO, HFD,
- GSE262879 Single-cell RNA-sequencing of murine pancreatic tumors derived from the orthotopic transplantation of Smad4 wild-type (WT) or Smad4 knockout (KO) pancreatic ductal adenocarcinoma (PDAC) KPC organoids in nu/nu mice. 18 samples shares rna-sequencing, wild-type, knockout
- GSE312324 RNA-sequencing analysis of wild-type, Lao1 knockout and Lao1/Il4i1 double knockout mice under normal and DSS-treated conditions 18 samples shares rna-sequencing, wild-type, knockout
- GSE262878 Single-cell RNA-sequencing of murine pancreatic tumors derived from the orthotopic transplantation of Smad4 wild-type (WT) or Smad4 knockout (KO) pancreatic ductal adenocarcinoma (PDAC) KvPC organoids in nu/nu mice 8 samples shares rna-sequencing, wild-type, knockout
- GSE277039 RNA-sequencing of primary wild-type (WT) and Pla2g4d-deficient (KO) keratinocytes 26 samples shares rna-sequencing, wild-type
- GSE293584 RNA-sequencing of SVF-derived preadipocytes and adipocytes from inguinal white adipose tissue of male mice treated with vehicle, CGRPa, NPY, NE, or SP 21 samples shares rna-sequencing, inguinal
- GSE247475 Bulk RNA-sequencing of synovial macrophages (wild-type) 18 samples shares rna-sequencing, wild-type
- GSE283700 RNA-sequencing of SVF-derived preadipocytes from inguinal adipose tissue of male mice differentiating under control conditions or treated with CGRP 15 samples shares rna-sequencing, inguinal
- GSE267926 Single-cell RNA-Sequencing of Wild-type Perinatal Mice Thymi 11 samples shares rna-sequencing, wild-type
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.