ATAD2 drives HIRA/histone H3.3-dependent chromatin dynamics
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 8 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ATAD2 mediates chromatin-bound histone chaperone turnovereLife · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277943_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1164783 and SRA study SRP534532. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 8 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8534998 testis, d20_ko_rep1 testis, d20_ko
- GSM8534999 testis, d20_ko_rep2 testis, d20_ko
- GSM8535000 testis, d20_ko_rep3 testis, d20_ko
- GSM8535001 testis, d20_ko_rep4 testis, d20_ko
- GSM8535002 testis, d20_wt_rep1 testis, d20_wt
- GSM8535003 testis, d20_wt_rep2 testis, d20_wt
- GSM8535004 testis, d20_wt_rep3 testis, d20_wt
- GSM8535005 testis, d20_wt_rep4 testis, d20_wt
- GSM8535006 testis, d22_ko_rep1 testis, d22_ko
- GSM8535007 testis, d22_ko_rep2 testis, d22_ko
- GSM8535008 testis, d22_ko_rep3 testis, d22_ko
- GSM8535009 testis, d22_ko_rep4 testis, d22_ko
- GSM8535010 testis, d22_wt_rep1 testis, d22_wt
- GSM8535011 testis, d22_wt_rep2 testis, d22_wt
- GSM8535012 testis, d22_wt_rep3 testis, d22_wt
- GSM8535013 testis, d22_wt_rep4 testis, d22_wt
- GSM8535014 testis, d24_ko_rep1 testis, d24_ko
- GSM8535015 testis, d24_ko_rep2 testis, d24_ko
- GSM8535016 testis, d24_wt_rep1 testis, d24_wt
- GSM8535017 testis, d24_wt_rep2 testis, d24_wt
- GSM8535018 testis, d26_ko_rep1 testis, d26_ko
- GSM8535019 testis, d26_ko_rep2 testis, d26_ko
- GSM8535020 testis, d26_wt_rep1 testis, d26_wt
- GSM8535021 testis, d26_wt_rep2 testis, d26_wt
- GSE237916 Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction 197 samples shares chromatin, histone
- GSE283483 Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression programs in the hippocampus 160 samples shares chromatin, drives
- GSE288605 Context-Dependent and Gene-Specific Role of Chromatin Architecture Mediated by Histone Modifiers and Loop-extrusion Machinery 96 samples shares chromatin, histone
- GSE204933 Age-associated chromatin reorganization drives overexpression of a novel Btaf1 variant regulating HSC self-renewal and MkP differentiation in male mice 82 samples shares chromatin, drives
- GSE264193 H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos [ChIP-seq] 57 samples shares chromatin, dynamics
- GSE241262 Histone marks enable formation of immiscible phase-separated chromatin compartments 35 samples shares chromatin, histone
- GSE234065 Unexpected nuclear hormone receptor and chromatin dynamics regulate estrous cycle dependent gene expression 32 samples shares chromatin, dynamics
- GSE306869 The RNA binding protein LIN28A mediates chromatin dynamics during neuronal differentiation 24 samples shares chromatin, dynamics
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.