GEO series
Identification of lipid senolytics targeting senescent cells through ferroptosis induction
GSE278372
Mus musculus
Expression profiling by high throughput sequencing
45 samples
2024/10/07
GPL24247
Summary
Through phenotypic drug screening, we identified a novel class of lipid senolytics that selectively eliminated a broad range of senescent cells, reduced tissue senescence, and extended healthspan in mice. Extensive mechanistic studies reveal that these lipids induce ferroptotic cell death by exploiting the iron-rich and ROS-prone characteristics of senescent cells, offering a new therapeutic strategy to target senescence in aging and age-related diseases.
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Paper (PMID 39463954) ↗
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