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Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas

GSE292815 Mus musculus (mouse) RNA-seq (gene expression) 39 samples Submitted 2026/04/10 Platform GPL24247
At a glance

RNA-seq (gene expression) · mouse · 39 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
39 samples: 10 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreasCancer discovery · 2026
Summary (written by the submitters)
High-fat diet (HFD) intake has been linked to an increased risk of pancreatic ductal adenocarcinoma (PDAC), a lethal and therapy-resistant cancer. However, whether and how specific dietary fats drive cancer development remains unresolved. Leveraging an oncogenic Kras-driven mouse model that closely mimics human PDAC progression, we screened a dozen isocaloric HFDs differing solely in fat source and representing the diversity of human fat consumption.
Read the full summary ↓
Unexpectedly, diets rich in oleic acid - a monounsaturated fatty acid (MUFA) typically associated with good health - markedly enhanced tumorigenesis. Conversely, diets high in polyunsaturated fatty acids (PUFAs) suppressed tumor progression. Relative dietary fatty acid saturation levels (PUFA/MUFA) governed pancreatic membrane phospholipid composition, lipid peroxidation, and ferroptosis sensitivity in mice, concordant with circulating PUFA/MUFA levels being linked to altered PDAC risk in humans. These findings directly implicate dietary unsaturated fatty acids in controlling ferroptosis susceptibility and tumorigenesis, supporting potential "precision nutrition" strategies for PDAC prevention.
Published in
Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas
Ruiz CF, Ge X, McDonnell R et al. · Cancer discovery 2026 · PMID 42053430 · doi:10.1158/2159-8290.CD-25-0734
This dataset
Open GSE292815 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE292815_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1241296 and SRA study SRP572780. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 42053430) ↗
Study design
10 conditions, mostly with about 5 replicates each
pancreas, CD, 12-week on diet, male, ×5 pancreas, Safflower, 12-week on diet, male, ×5 pancreas, Safflower, 8-week on diet, female, K ×5 pancreas, Safflower, 8-week on diet, male, K ×5 pancreas, HO Safflower, 12-week on diet, male, ×4 pancreas, Sunflower, 12-week on diet, male, ×4 pancreas, HO Safflower, 3-week on diet, male, ×4 pancreas, HO Sunflower, 12-week on diet, male, ×3 +2 more

Supports a between-group comparison across 39 samples.

How we read this: 10 replicated groups read from 39 sample titles; they account for 39 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
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