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The causative effect of CXCR7 on experimental autoimmune prostatitis injury and fibrosis

GSE278520 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/09/30 Platform GPL24247
Summary
The purpose of this study is to further understand the changes in mRNA expression in the prostate tissue of EAP mice after the use of VUF11207. After establishing the EAP mouse model, the experimental group was intraperitoneally injected with VUF11207, while the control group was intraperitoneally injected with an equal amount of DMSO solvent. After continuous injection for 14 days, the mRNA expression in the mouse prostate was sequenced and analyzed. Using RNA-Seq technology, a large number of differentially expressed genes were identified at the whole-genome level. Our study suggests that compared to the control group, under the action of VUF11207, CXCR7 can cause prostate epithelial cell damage and fibrosis.
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Also filed as BioProject PRJNA1167700 and SRA study SRP535965. Searching any of these in the dataset finder brings you back here.

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