GEO series
Chromatin accessibility profiles of activated hematopoietic stem cells under several conditions [ATAC-Seq]
GSE279407
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
17 samples
2026/07/13
GPL21273
Summary
Self-renewing hematopoietic stem cells (HSCs) during hematopoietic regeneration showed lower intracellular glutamate (Glu) levels compared with dividing progenitor cells in the steady state and HSCs that attenuate stem cell features during ex vivo culture. Moreover, R162, an inhibitor of glutamine dehydrogenase (Glud1) that catabolize Glu into α-ketoglutarate, contributed to stem cell maintenance during HSC divisions. These data suggest that lower intracellular Glu levels during HSC division contributed to self-renewing divisions by suppressing Glud1-mediated reactions.
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