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Effects of engineered IL-18BP on attenuation of hepatic stellate cell activation

GSE279499 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/10/18 Platform GPL21626
Summary
Metabolic dysfunction-associated steatohepatitis (MASH) is a chronic liver disease associated with hepatic inflammation and fibrosis. Inflammasome-mediated IL-18 signaling is enhanced under MASH condition. IL-18 binding protein (IL-18BP) is a soluble protein that can block IL-18 actions and therapeutic potential of IL-18BP for MASH-induced fibrosis is largely unknown. We newly developed a human IL-18BP biologics (APB-R3) and injected it to mice to evaluate its pharmacologic efficacy. APB-R3 strikingly abolished hepatic fibrosis and reduced collagen markers. We further investigated whether APB-R3 could inhibit fibrotic activation of hepatic stellate cells (HSCs). This study proposes that abrogation of IL-18 signaling by boosting IL-18BP can strongly inhibit the development of MASH-induced fibrosis and our engineered IL-18BP biologics can become promising therapeutic candidate for curing MASH.
Published in
Treatment of IL-18-binding protein biologics suppresses fibrotic progression in metabolic dysfunction-associated steatohepatitis
Kim DH, Choi G, Song EB et al. · Cell reports. Medicine 2025 · PMID 40239621 · doi:10.1016/j.xcrm.2025.102047
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Also filed as BioProject PRJNA1173149 and SRA study SRP538661. Searching any of these in the dataset finder brings you back here.

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