Dux cluster duplication ensures full activation of totipotent genes
RNA-seq (gene expression) · mouse · 22 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 22 samples: 9 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE280037_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1176008 and SRA study SRP540160. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 22 samples.
How we read this: 9 replicated groups read from 22 sample titles; they account for 22 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8586027 RNA-Seq, E14-chen-1 RNA-Seq, E14-chen
- GSM8586028 RNA-Seq, E14-chen-2 RNA-Seq, E14-chen
- GSM8586029 RNA-Seq, E14-chen-3 RNA-Seq, E14-chen
- GSM8586030 RNA-Seq, Dux-KO-15 RNA-Seq, Dux-KO
- GSM8586031 RNA-Seq, Dux-KO-22 RNA-Seq, Dux-KO
- GSM8586032 RNA-Seq, Dux-KO-52 RNA-Seq, Dux-KO
- GSM8586033 RNA-Seq, Duxnto1-17 RNA-Seq, Duxnto1
- GSM8586034 RNA-Seq, Duxnto1-22 RNA-Seq, Duxnto1
- GSM8586035 RNA-Seq, Duxnto1-31 RNA-Seq, Duxnto1
- GSM8586036 RNA-Seq, Duxnto1-40 RNA-Seq, Duxnto1
- GSM8586037 RNA-Seq, Dux-KO22-DMSO-1 RNA-Seq, Dux-KO22-DMSO
- GSM8586038 RNA-Seq, Dux-KO22-DMSO-2 RNA-Seq, Dux-KO22-DMSO
- GSM8586039 RNA-Seq, Dux-N22-DMSO-1 RNA-Seq, Dux-N22-DMSO
- GSM8586040 RNA-Seq, Dux-N22-DMSO-2 RNA-Seq, Dux-N22-DMSO
- GSM8586041 RNA-Seq, WT-DMSO-1 RNA-Seq, WT-DMSO
- GSM8586042 RNA-Seq, WT-DMSO-2 RNA-Seq, WT-DMSO
- GSM8586043 RNA-Seq, WT-GSK-1 RNA-Seq, WT-GSK
- GSM8586044 RNA-Seq, WT-GSK-2 RNA-Seq, WT-GSK
- GSM8586045 RNA-Seq, Dux-KO22-GSK-1 RNA-Seq, Dux-KO22-GSK
- GSM8586046 RNA-Seq, Dux-KO22-GSK-2 RNA-Seq, Dux-KO22-GSK
- GSM8586047 RNA-Seq, Dux-N22-GSK-1 RNA-Seq, Dux-N22-GSK
- GSM8586048 RNA-Seq, Dux-N22-GSK-2 RNA-Seq, Dux-N22-GSK
- GSE255212 Transcriptomic Signatures of WNT-Driven Pathways and Granulosa Cell-Oocyte Interaction during Primordial Follicle Activation 762 samples shares activation
- GSE331176 Phagosome-mediated activation of STING by purine and pyrimidine-based bacterial cyclic dinucleotides 380 samples shares activation
- GSE292862 Modelling mouse embryogenesis from chemically induced totipotent stem cells 22 samples shares totipotent
- GSE243942 Spatio-temporal X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing [RNA-seq] 125 samples shares activation
- GSE295196 m6A RNA methylation in the maintenance of X-chromosome inactivation and X to autosome dosage compensation in early embryogenesis [RNA-Seq] 14 samples shares activation
- GSE297515 Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging 90 samples shares activation
- GSE236129 Activation of RAS/MEK/ERK signaling drives biliary differentiation in primary liver cancer [112UE] 80 samples shares activation
- GSE201228 CD4+ T cell activation in absence of WNK1 72 samples shares activation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.