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Evaluation of PFHxS, PFOA, PFOS, and PFNA impact on liver metabolism using human liver spheroids

GSE280527 Homo sapiens Expression profiling by high throughput sequencing 7 samples Submitted 2025/08/27 Platform GPL18573
Summary
Accumulating evidence suggests that poly- and perfluoroalkyl substances (PFAS), a class of persistent organic pollutants, cause changes in hepatic lipid, amino acid, and glucose metabolism. Our study explores the molecular mechanisms whereby PFHxS, PFOA, PFOS, and PFNA disrupt liver metabolism.
Published in
Assessing the impact of perfluoroalkyl substances on liver health: a comprehensive study using multi-donor human liver spheroids
Golden-Mason L, Salomon MP, Matsuba C et al. · Environment international 2025 · PMID 40914107 · doi:10.1016/j.envint.2025.109763
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Also filed as BioProject PRJNA1179350 and SRA study SRP541753. Searching any of these in the dataset finder brings you back here.

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