GEO series
Gonadal sex reversal at single-cell resolution in Znrf3-deficient mice
GSE280999
Mus musculus
Expression profiling by high throughput sequencing
35 samples
2024/11/29
GPL24247
Summary
Early gonadal-mesonephros tissues give rise to the developing gonad, with potential to diverge towards either a testis or ovarian gonadal fate. ZNRF3 mutant homozygotic mice develop a variable sex reversal previously uncharacterised at the single cell level. We used scRNA-Seq to compare XX and XY WT C57BL/6J mouse gonads to ZNRF3-deficient mice across multiple timepoints, during and after initial sex determination.
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Paper (PMID 39629665) ↗
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