Skeletal muscle specific overexpression of miRNA-1 impairs mechanical overload-induced skeletal muscle hypertrophy [RNA-Seq]
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 5 × Sham_control_A vs 5 × Sham_mimic_B vs 5 × OV_control_C vs 5 × OV_mimic_DGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- miRNA-1 regulation is necessary for mechanical overload-induced muscle hypertrophy in male micePhysiological reports · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE265982_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1105087 and SRA study SRP504287. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 4 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8238998 Sham_control_A1 Sham_control_A
- GSM8238999 Sham_control_A2 Sham_control_A
- GSM8239000 Sham_control_A3 Sham_control_A
- GSM8239001 Sham_control_A4 Sham_control_A
- GSM8239002 Sham_control_A5 Sham_control_A
- GSM8239003 Sham_mimic_B1 Sham_mimic_B
- GSM8239004 Sham_mimic_B2 Sham_mimic_B
- GSM8239005 Sham_mimic_B3 Sham_mimic_B
- GSM8239006 Sham_mimic_B4 Sham_mimic_B
- GSM8239007 Sham_mimic_B5 Sham_mimic_B
- GSM8239008 OV_control_C1 OV_control_C
- GSM8239009 OV_control_C2 OV_control_C
- GSM8239010 OV_control_C3 OV_control_C
- GSM8239011 OV_control_C4 OV_control_C
- GSM8239012 OV_control_C5 OV_control_C
- GSM8239013 OV_mimic_D1 OV_mimic_D
- GSM8239014 OV_mimic_D2 OV_mimic_D
- GSM8239015 OV_mimic_D3 OV_mimic_D
- GSM8239016 OV_mimic_D4 OV_mimic_D
- GSM8239017 OV_mimic_D5 OV_mimic_D
- GSE284286 Cardiomyocyte-specific LARP6 overexpression prevents Angiotensin II-induced myocardial dysfunction and interstitial fibrosis 50 samples shares overexpression, specific
- GSE280171 Myofibre-specific knockout of TGF-β type I receptors triggers muscle hypertrophy and promotes contraction and oxidative metabolism 32 samples shares hypertrophy, specific
- GSE252607 Cardiomyocyte specific RXFP1-overexpression protects Relaxin-independently from pressure-overload induced cardiac dysfunction 30 samples shares overexpression, specific
- GSE293093 RNA Seq of hearts upon hepatocyte-specific overexpression of REV-ERBα in cancer cachexia 29 samples shares overexpression, specific
- GSE241180 Fibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes 27 samples shares hypertrophy, specific
- GSE262341 Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways 13 samples shares overexpression, skeletal
- GSE244213 Liver transcriptomic profile of 6 months old wild type and hepatocyte-specific ATF6 overexpression mice 13 samples shares overexpression, specific
- GSE241176 Fibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes [RNA-seq: Smad3 in dbdb] 12 samples shares hypertrophy, specific
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.