← BioTransfer GEO Dataset Finder
GEO series

The effects of IL-16 deficience on gene expression after 24 week high-fat diet in mice

GSE281663 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/11/12 Platform GPL24247
Summary
IL16-/-ApoE-/- mice and ApoE-/- mice were fed with high-fat diet for 24 weeks. The aortas from the two group mice were isolated for RNA-sequencing. Results showed that IL16-/- deletion caused a total of 1201 genes was altered, of which 943 genes were upregulated and 258 genes were downregulated in mice. Genes encoding membrane and extracellular components were remarkably enriched by Gene Ontology (GO) analysis, such as Collagen I α1 (ColIα1), ColIα2, Elastin, Filamin-α (Flnα), integrin beta 1 (Itgb1) and TIMP-3.
Published in
Interleukin-16 upregulates tissue inhibitor of metalloproteinase 3 to promote atherosclerotic plaque stability
He H, Ding M, Zhu Y et al. · Journal of translational medicine 2026 · PMID 41555435 · doi:10.1186/s12967-025-07663-0
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE281663_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1185187 and SRA study SRP544694. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.