GEO series
Cross-sectional study of human spermatozoa mRNA from infertility study participants and proven-fertile control participants
GSE281732
Homo sapiens
Expression profiling by high throughput sequencing
70 samples
2025/01/16
GPL20301
Summary
The goal of this study was to identify mRNAs in spermatozoa that differ between idiopathic infertile men and proven-fertile men. The rationale is that there are many idiopathic infertile or subfertile men, and that semen parameters cannot reliably distinguish idopathic infertile men from fertile men. Spermatozoa contain thousands of RNAs, and the levels of those RNAs may reflect the extent of normal spermatogenesis and sperm maturation. We hypothesized that we could identify differences between two patient populations that would reflect their clinical fertility status.
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Paper (PMID 40346865) ↗
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