Transcriptome analysis of quiescent livers and regenerating livers after partial hepatectomy (PH) in young and aged mice
RNA-seq (gene expression) · mouse · 133 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 133 samples: 129 distinct titles, 4 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Differential Effects of Liver Regeneration on Aging-Related Changes in Gene Expression and Metabolic FunctionAging cell · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE282210_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1187589 and SRA study SRP545982. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 133 sample titles: 129 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8639134 YF_Ctrl_1_mix2
- GSM8639135 YF_Ctrl_2_mix2
- GSM8639136 YF_Ctrl_3_mix2
- GSM8639137 YF_52h_1_mix3
- GSM8639138 YF_52h_2_mix3
- GSM8639139 YF_Sh2d_1_mix3
- GSM8639140 YF_Sh2d_2_mix3
- GSM8639141 YF_4d_1_mix4
- GSM8639142 YF_4d_2_mix4
- GSM8639143 YF_Sh4d_1_mix4
- GSM8639144 YF_Sh4d_2_mix4
- GSM8639145 YM_Ctrl_1X_mix1
- GSM8639146 YM_Ctrl_2X_mix1
- GSM8639147 YM_Ctrl_3X_mix1
- GSM8639148 OF_Ctrl_1X_mix1
- GSM8639149 OF_Ctrl_2X_mix1
- GSM8639150 OF_Ctrl_3X_mix1
- GSM8639151 VOF_Ctrl_1_mix2
- GSM8639152 VOF_Ctrl_2_mix2
- GSM8639153 VOF_Ctrl_3_mix2
- GSM8639154 VOF_52h_1_mix5
- GSM8639155 VOF_52h_2_mix5
- GSM8639156 VOF_Sh2d_1_mix5
- GSM8639157 VOF_Sh2d_2_mix5
- GSM8639158 VOF_4d_1_mix6
- GSM8639159 VOF_4d_2_mix6
- GSM8639160 VOF_Sh4d_1_mix6
- GSM8639161 VOF_Sh4d_2_mix6
- GSM8639162 YM_Ctrl_1_mix7
- GSM8639163 YM_Ctrl_2_mix7
- GSM8639164 YM_Ctrl_3_mix7
- GSM8639165 VOM_Ctrl_1_mix8
- GSM8639166 VOM_Ctrl_2_mix8
- GSM8639167 VOM_Ctrl_3_mix8
- GSM8639168 VOM_52h_1_mix9
- GSM8639169 VOM_52h_2_mix9
- GSM8639170 VOM_52h_3X_mix9
- GSM8639171 VOM_Sh2d_1_mix9
- GSM8639172 VOM_Sh2d_2_mix9
- GSM8639173 VOM_Sh2d_3_mix9
+ 93 more — browse all 133 samples with per-sample file links →
- GSE256002 Comparison of transcriptional changes in regenerating mice livers at baseline and 24-48 hours post 70% partial hepatectomy with or without etomoxir treatment 27 samples shares regenerating, hepatectomy, partial, livers
- GSE255995 Comparison of transcriptional changes in regenerating mice livers at baseline and 3-12 hours post 70% partial hepatectomy 12 samples shares regenerating, hepatectomy, partial, livers
- GSE281923 Gene expression profiling by bulk RNAseq from the livers of wild-type mice and those with loss-of-function mutations in URI 48 hours after partial hepatectomy 8 samples shares hepatectomy, partial, livers
- GSE191188 Droplet-based RNA sequencing of single cells from injured and regenerating skeletal muscles of young and aged mice 5 samples shares regenerating, young, aged
- GSE255292 H3K27ac CUT&Tag of regenerating liver after 70% partial hepatectomy 4 samples shares regenerating, hepatectomy, partial
- GSE271744 Bulk RNAseq of mononucleated cells isolated from resting and regenerating adult and aged skeletal mouse muscle 107 samples shares regenerating, aged
- GSE328885 Liver transcriptomic response to partial hepatectomy in intestinal-specific SIRT1 knockout mice 34 samples shares hepatectomy, partial
- GSE329873 Transcriptomic analysis of hepatocyte specific Eed knock out compared to wild type mice before and after partial hepatectomy 20 samples shares hepatectomy, partial
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.