GEO series
Single cell RNA sequencing of different Kupffer cell subsets in a mycobacterial infection
GSE282492
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2026/06/04
GPL24247
Summary
Kupffer cells can be distinguished in three subpopulations during mycobacterial infection based on the expression of Tim4 and the fluorochrome tdTomato within Clec4fCre-tdTomato-NLS: ROSA26EYFP mice. These subpopulations differ in their origin and tissue localization. The aim of this scRNA sequencing was to understand the heterogeneity of macrophages and monocytes during the peak of the infection (4 weeks) and the resolution (10 weeks) and understand their dynamics.
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