KMT2D controls cerebellar granule cell differentiation by temporally activating neuronal transcriptional factor genes
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 18 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- KMT2D temporally activates neuronal transcriptional factor genes to mediate cerebellar granule cell differentiationScience advances · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE282804_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1190436 and SRA study SRP547477. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8650760 GCP-CB cells, IgG, Control, replicate 1, SD1, Input
- GSM8650761 GCP-CB cells, H3K27ac, Control, replicate 1, SD2, CUT&RUN
- GSM8650762 GCP-CB cells, H3K27ac, Control, replicate 2, SD3, CUT&RUN
- GSM8650763 GCP-CB cells, IgG, KO, replicate 1, SD4, Input
- GSM8650764 GCP-CB cells, H3K27ac, KO, replicate 1, SD5, CUT&RUN
- GSM8650765 GCP-CB cells, H3K7ac, KO, replicate 2, SD6, CUT&RUN
- GSM8650766 GCP-CB cells, KMT2D, Control, replicate 1, SD2, CUT&RUN
- GSM8650767 GCP-CB cells, KMT2D, Control, replicate 2, SD3, CUT&RUN
- GSM8650768 GCP-CB cells, KMT2D, KO, replicate 1, SD5, CUT&RUN
- GSM8650769 GCP-CB cells, KMT2D, KO, replicate 2, SD6, CUT&RUN
- GSM8650770 GCP cells, Cerebellum, Control, 30d, replicate 1, RNA-seq
- GSM8650771 GCP cells, Cerebellum, Control, 30d, replicate 2, RNA-seq
- GSM8650772 GCP cells, Cerebellum, KO, 30d, replicate 1, RNA-seq
- GSM8650773 GCP cells, Cerebellum, KO, 30d, replicate 2, RNA-seq
- GSM8650774 GCP cells, Cerebellum, Control, 4m, replicate 1, RNA-seq
- GSM8650775 GCP cells, Cerebellum, Control, 4m, replicate 2, RNA-seq
- GSM8650776 GCP cells, Cerebellum, KO, 4m, replicate 1, RNA-seq
- GSM8650777 GCP cells, Cerebellum, KO, 4m, replicate 2, RNA-seq
- GSE282802 KMT2D controls cerebellar granule cell differentiation by temporally activating neuronal transcriptional factor genes [CUT&RUN] 10 samples shares kmt2d, cerebellar, temporally, activating, controls, neuronal, granule, factor
- GSE260623 Germline ELP1 deficiency sensitizes cerebellar granule neuron progenitors to SHH medulloblastoma [bulkRNA] 91 samples shares cerebellar, granule
- GSE279347 Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma [ChIP-seq] 32 samples shares cerebellar, granule
- GSE269938 Loss of Activating transcription factor 3 restricts KRASG12D’s ability to promote PanIN progression through epithelial specific transcriptional regulation 18 samples shares activating, factor
- GSE233650 The exposure of prenatal enriched environment promotes fetal neuronal development via activating AHR-Src pathway 16 samples shares activating, neuronal
- GSE279346 Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma [RNA-seq] 15 samples shares cerebellar, granule
- GSE273979 Platelet activating factor (PAF) promotes immunosuppressive neutrophil differentiation within tumors 12 samples shares activating, factor
- GSE298423 The role of ZNHIT3 in cerebellar granule cell development 12 samples shares cerebellar, granule
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.