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Astroglial Ezh2 regulates early astrocyte morphogenesis and affects the coverage of astrocyte endfeet on blood vessels

GSE283622 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/12/15 Platform GPL17021
Summary
To further investigate how Ezh2 derived from cortical astrocytes regulates cell morphology, RNA-seq analysis was performed to examine transcriptomic changes in cortical astrocytes isolated from Ezh2 conditional knockout mice and wild-type littermates at P5. Approximately 4,900 transcripts exhibited differential expression between Ezh2fl/fl and Ezh2-cKO-Aldh1l1 mouse cortical astrocytes, with a fold change ≥2 and a p-value <0.05. After further screening of the highly expressed gene subset among the differentially expressed genes, we found that the upregulated genes were enriched in processes related to gliogenesis, cell differentiation, and cytoskeletal organization. These findings highlight the critical role of astrocytic Ezh2 in the morphological development of astrocytes.
Published in
Ezh2 Regulates Early Astrocyte Morphogenesis and Influences the Coverage of Astrocytic Endfeet on the Vasculature
Zhao X, Zhang M, Zou W et al. · Cell proliferation 2025 · PMID 40022506 · doi:10.1111/cpr.70015
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Also filed as BioProject PRJNA1194629 and SRA study SRP549660. Searching any of these in the dataset finder brings you back here.

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