Human stem cell-derived GABAergic interneuron development reveals early emergence of subtype diversity followed by gradual electrochemical maturation [snRNA-seq]
Single-nucleus RNA-seq · human · 19 samples
- What it is
- Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue).
- Organism
- Homo sapiens (human)
- Samples
- 19 samples: 19 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE283776_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1195564 and SRA study SRP550078. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 19 sample titles: 19 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8672164 200319S,mpt1,batch 1
- GSM8672165 200319S,mpt6,batch 1
- GSM8672166 200319S,mpt18,batch 1
- GSM8672167 010519S1,pre,batch 2
- GSM8672168 010519S1,div30,batch 2
- GSM8672169 010519S1,dpt14,batch 2
- GSM8672170 010519S1,mpt1,batch 2
- GSM8672171 010519S1,mpt6,batch 2
- GSM8672172 150120S,pre,batch 6
- GSM8672173 150120S,mpt3,batch 6
- GSM8672174 150120S,mpt6,batch 6
- GSM8672175 150120S,mpt12,batch 6
- GSM8672176 150120S,mpt18,batch 6
- GSM8672177 220720S2,pre,batch 12
- GSM8672178 220720S2,mpt3,batch 12
- GSM8672179 220720S2,mpt6,batch 12
- GSM8672180 220720S2,mpt12,batch 12
- GSM8672181 260423S,mpt1,batch 15
- GSM8672182 260423S,mpt4,batch 15
- GSE283775 Human stem cell-derived GABAergic interneuron development reveals early emergence of subtype diversity followed by gradual electrochemical maturation [scRNA-seq] 14 samples shares electrochemical, cell-derived, interneuron, maturation, gabaergic, emergence, diversity
- GSE249826 Human-induced pluripotent Stem Cell-Derived Hepatic Stellate Cells in Liver Organoids: Maturation Promotion and Essential Role in Vascularization 26 samples shares cell-derived, maturation
- GSE268981 Graphene-polymer nanofibers enable optically induced electrical maturation in stem cell-derived cardiomyocytes and brain organoids 23 samples shares cell-derived, maturation
- GSE326651 in vivo human embryonic spinal cord atlas validates stem cell-derived human dorsal interneurons and reveals ASD spinal signatures [day0NMP_bulk RNAseq] 15 samples shares cell-derived, interneuron
- GSE326655 in vivo human embryonic spinal cord atlas validates stem cell-derived human dorsal interneurons and reveals ASD spinal signatures [day43NMP_scRNAseq] 12 samples shares cell-derived, interneuron
- GSE336395 Multi-omic analysis reveals maturation programs in human pluripotent stem cell-derived cardiomyocytes during long-term culture 11 samples shares cell-derived, maturation
- GSE262419 Informing Hazard Identification and Risk Characterization of Environmental Chemicals by Combining Transcriptomic and Functional Data from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes 4558 samples shares cell-derived
- GSE226482 Single cell RNA sequencing of spinal motor neurons and interneurons differentiated from isogenic FUS and TARDBP human induced pluripotent stem cell lines harbouring ALS-causative mutations 1415 samples shares interneuron
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.