Piezo1 promotes the progression of necrotizing enterocolitis via activating Ca2(+)/CaMKII-dependent pathway
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × Piezo1 flox_control vs 3 × Piezo1 flox_NEC vs 3 × Piezo1 CKO_control vs 3 × Piezo1 CKO_NECGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Piezo1 promotes the progression of necrotizing enterocolitis by activating the Ca2(+)/CaMKII-dependent pathwayCommunications biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE283887_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1195969 and SRA study SRP550294. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8673864 Piezo1 flox_control1 Piezo1 flox_control
- GSM8673865 Piezo1 flox_control2 Piezo1 flox_control
- GSM8673866 Piezo1 flox_control3 Piezo1 flox_control
- GSM8673867 Piezo1 flox_NEC1 Piezo1 flox_NEC
- GSM8673868 Piezo1 flox_NEC2 Piezo1 flox_NEC
- GSM8673869 Piezo1 flox_NEC3 Piezo1 flox_NEC
- GSM8673870 Piezo1 CKO_control1 Piezo1 CKO_control
- GSM8673871 Piezo1 CKO_control2 Piezo1 CKO_control
- GSM8673872 Piezo1 CKO_control3 Piezo1 CKO_control
- GSM8673873 Piezo1 CKO_NEC1 Piezo1 CKO_NEC
- GSM8673874 Piezo1 CKO_NEC2 Piezo1 CKO_NEC
- GSM8673875 Piezo1 CKO_NEC3 Piezo1 CKO_NEC
- GSE318580 The RNA-binding protein Imp1 promotes a Spdef transcriptional program and mucus fucosylation during necrotizing enterocolitis 32 samples shares enterocolitis, necrotizing, promotes
- GSE298695 Mechanosensing by endothelial Piezo1 promotes liver regeneration after partial hepatectomy via ATF2-ID1-Wnt2 pathway 16 samples shares piezo1, promotes
- GSE291140 AMPK suppresses multiple cell death pathways to sustain tumor-associated macrophage proportion and promotes tumor progression 12 samples shares progression, promotes
- GSE281618 Cataloguing the postnatal small intestinal transcriptome during the period of susceptibility to necrotizing enterocolitis 48 samples shares enterocolitis, necrotizing
- GSE311895 Stiffness-related mitochondria transfer promotes tumor progression through metabolic reprogramming 18 samples shares progression, promotes
- GSE328178 Genetic suppression of myeloid receptor Clec7a attenuates microglia neuroinflammation and promotes microglial phagocytosis to delay disease progression in ALS models 14 samples shares progression, promotes
- GSE274650 G3BP1 translocates into mitochondria to impair MCU complex function and promotes NASH progression [G3bp1-HKO and G3bp1-Flox mice with BSA or PA treatment] 12 samples shares progression, promotes
- GSE241850 Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer progression via extracellular vesicle transfer of m6A-modified RNAs 57 samples shares progression, promotes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.