← BioTransfer GEO Dataset Finder
GEO series

Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance [scRNA-Seq]

GSE284051 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/01/03 Platform GPL24247
Summary
Macrophages were identified in the pituitary gland long ago, but until recently, we lacked the resolution to comprehensively profile the pituitary gland macrophage compartment. To address this, we examined the developmental kinetics and distinctive characteristics of pituitary macrophages within the developing and homeostatic gland. Whole pituitary glands were collected from newborn (NB) to adult (8 weeks old) wild-type (WT) mice. Our analysis revealed diverse macrophage subsets with marked differences in gene expression profiles and spatial localization, undergoing dynamic phenotypic changes from neonatal stages to adulthood. We observed distinct transcriptional profiles between macrophage subpopulations in the anterior and posterior lobes, underscoring significant molecular divergences. Fate-mapping analyses showed that pituitary macrophages originate from early yolk sac precursors and persist throughout life primarily through local proliferation, even under pathophysiological conditions.
Published in
Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance
Lehtonen H, Jokela H, Hofmann J et al. · Cell reports 2025 · PMID 39841599 · doi:10.1016/j.celrep.2024.115227
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE284051_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1196908 and SRA study SRP550806. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.