GEO series
Obesity promotes inflammatory, metabolic, and proliferative transcriptional programs in orthotopically transplanted murine colon tumors
GSE284066
Mus musculus
Expression profiling by high throughput sequencing
15 samples
2025/10/06
GPL21103
Summary
The mechanisms driving obesity-associated colon cancer progression are not completely understood. This study leveraged RNA sequencing data from control and obese C57BL/6 mice to identify obesity-associated transcriptomic signatures. Bulk EpCAM+ epithelial tumor transcriptomic analyses revealed obesity-driven enrichment of inflammation, proliferation, and metabolic pathways.
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Paper (PMID 40998019) ↗
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