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Dissecting the effects of sequence on transcription attenuation by the Restrictor complex [RNA-Seq]

GSE284375 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/23 Platform GPL24247
Summary
The eukaryotic genome is actively transcribed by RNA Polymerase II (RNAPII) to produce both messenger RNAs (mRNAs) and a repertoire of non-coding RNAs (ncRNAs). For genome integrity, RNAPII elongation and termination is tightly regulated to enable the full-length synthesis of mRNAs and the rapid turnover of many ncRNAs. The Restrictor Complex has recently been implicated in attenuating the expression of many ncRNAs, however the mechanism by which Restrictor suppresses gene expression remains unclear. Here, we address central questions regarding the specificity of Restrictor-mediated transcription attenuation.
Published in
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci
Mimoso CA, Vlaming H, de Wagenaar NP et al. · Genes & development 2025 · PMID 40393801 · doi:10.1101/gad.352654.125
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Also filed as BioProject PRJNA1198914 and SRA study SRP551805. Searching any of these in the dataset finder brings you back here.

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