GEO series
Enhancing PARP inhibitor treatment efficacy for urothelial carcinoma by new biomarkers and synergistic combination treatment with bromodomain protein inhibitor PLX51107
GSE285648
Homo sapiens
Expression profiling by high throughput sequencing
36 samples
2025/10/01
GPL30173
Summary
We characterized cellular and molecular effects of the PARP inhibitor (PARPi) Olaparib compared to Talazoparib in bladder cancer cell lines and their Cisplatin pre-treated sublines. We aimed to identify common target genes of both PARPi and differences in mechanism of action to understand resistance mechanisms and identify new PARPi response marker for bladder cancer. RNA was submitted to RNA sequencing analysis on the NextSeq2000 system (Illumina).
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Paper (PMID 41216708) ↗
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