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Deciphering the Role of IGFBP5 in Delaying Fibrosis and Sarcopenia in Aging Skeletal Muscle

GSE285869 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/09 Platform GPL24247
Summary
D-galactose (D-gal) is a widely used chemical to induce cellular senescence. Cells undergoing senescence induced by D-gal exhibit mitochondrial structural damage and a decline in energy metabolism, which are highly related to cellular aging Studies have confirmed that D-gal can induce senescence, fibrosis, and redox imbalance in skeletal muscle fibroblasts. Our results confirm that D-galactose effectively induces cellular senescence and skeletal muscle fibrosis in both cellular and animal models. The increase in senescence markers and fibrosis-related proteins, along with the observed decline in muscle strength and mass, are consistent with previous studies that highlight the role of D-galactose in modeling aging-associated pathologies. The observed lethargy and reduction in muscle fiber cross-sectional area further validate the model's relevance to sarcopenia research.
Published in
Deciphering the role of IGFBP5 in delaying fibrosis and sarcopenia in aging skeletal muscle: therapeutic implications and molecular mechanisms
Shi L, Ding Z, Chen J · Frontiers in pharmacology 2025 · PMID 40144669 · doi:10.3389/fphar.2025.1557703
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Also filed as BioProject PRJNA1206476 and SRA study SRP555300. Searching any of these in the dataset finder brings you back here.

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