Selective targeting of endothelial and perivascular ROCK2 reverses liver fibrosis in pigs and human patients
RNA-seq (gene expression) · human · 36 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Nasopharyngeal carcinomaThis series is part of our curated briefing on it.
- Samples
- 36 samples: 21 × Fibrosis vs 6 × MASH vs 6 × Treatment vs 3 × ControlGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Selective targeting of endothelial and perivascular angiocrine ROCK2 treats liver fibrosisCell · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE290642_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1229477 and SRA study SRP566789. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 36 samples.
How we read this: 4 replicated groups read from 36 sample titles; they account for 36 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8818766 Fibrosis_1 Fibrosis
- GSM8818767 Fibrosis_2 Fibrosis
- GSM8818768 Fibrosis_3 Fibrosis
- GSM8818769 Fibrosis_4 Fibrosis
- GSM8818770 Fibrosis_5 Fibrosis
- GSM8818771 Fibrosis_6 Fibrosis
- GSM8818772 Fibrosis_7 Fibrosis
- GSM8818773 Fibrosis_8 Fibrosis
- GSM8818774 Fibrosis_9 Fibrosis
- GSM8818775 Fibrosis_10 Fibrosis
- GSM8818776 Fibrosis_11 Fibrosis
- GSM8818777 Fibrosis_12 Fibrosis
- GSM8818778 Fibrosis_13 Fibrosis
- GSM9472816 Fibrosis_14 Fibrosis
- GSM9472817 Fibrosis_15 Fibrosis
- GSM9472818 Fibrosis_16 Fibrosis
- GSM9472819 Fibrosis_17 Fibrosis
- GSM9472820 Fibrosis_18 Fibrosis
- GSM9472821 Fibrosis_19 Fibrosis
- GSM9472822 Fibrosis_20 Fibrosis
- GSM9472823 Fibrosis_21 Fibrosis
- GSM9472824 Control_1 Control
- GSM9472825 Control_2 Control
- GSM9472826 Control_3 Control
- GSM9473654 MASH-1 MASH
- GSM9473655 MASH-2 MASH
- GSM9473656 MASH-3 MASH
- GSM9473657 MASH-4 MASH
- GSM9473658 MASH-5 MASH
- GSM9473659 MASH-6 MASH
- GSM9473660 Treatment-1 Treatment
- GSM9473661 Treatment-2 Treatment
- GSM9473662 Treatment-3 Treatment
- GSM9473663 Treatment-4 Treatment
- GSM9473664 Treatment-5 Treatment
- GSM9473665 Treatment-6 Treatment
- GSE286069 MMP12-dependent myofibroblast formation contributes to the nucleus pulposus fibrosis and intervertebral disc degeneration 15 samples same disease briefing · shares fibrosis
- GSE295454 Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of nasopharyngeal carcinoma for therapeutic targeting 6 samples same disease briefing · shares targeting
- GSE289272 Interferon responsive high endothelial venules drive tumor tertiary lymphoid structure formation and predict response to anti-PD-1 immunotherapy in nasopharyngeal carcinoma 55 samples same disease briefing · shares endothelial
- GSE102349 Genomic Analysis of Nasopharyngeal Carcinoma Reveals TME-based Subtypes 113 samples same disease briefing
- GSE231572 Development and validation of a microbiota signature to predict prognosis in nasopharyngeal carcinoma 64 samples same disease briefing
- GSE277900 ZIKV infection series in paediaitric brain tumour and NPC cell lines 61 samples same disease briefing
- GSE120926 Single-cell RNA sequencing defines the interplay between tumor cells, virus and microenvironment in nasopharyngeal carcinoma 56 samples same disease briefing
- GSE282685 NPC-derived exosome-mediated effects on macrophages 35 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.