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Integrated network pharmacology and transcriptomics to explore the mechanism of Gui-qi-yi-shen granules in the treatment of IgA nephropathy

GSE286126 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/05/01 Platform GPL24247
Summary
To elucidate the underlying therapeutic mechanisms of Gui-qi-yi-shen granules (GQYS) in the treatment of IgAN, we have employed transcriptome sequencing of 9 mice kidney samples. 155 differentially genes were identified between IgAN and control groups, with 125 upregulated and 30 downregulated. Meanwhile, 403 genes differed between GQYS and IgAN groups, including 171 upregulated and 332 downregulated genes.
Published in
Integrative Network Pharmacology and Transcriptomics Reveal the Mechanism of Gui-Qi-Yi-Shen Granules in the Treatment of IgA Nephropathy
Cao JW, Tang YW, Jiang MY et al. · Drug design, development and therapy 2025 · PMID 40727923 · doi:10.2147/DDDT.S526706
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Also filed as BioProject PRJNA1207967 and SRA study SRP556090. Searching any of these in the dataset finder brings you back here.

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