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Disruption of the Novel Nested Gene Aff3ir Mediates Disturbed Flow-Induced Atherosclerosis in Mice

GSE286206 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/14 Platform GPL28457
Summary
Disturbed shear stress-induced endothelial atherogenic responses are pivotal in the initiation and progression of atherosclerosis, contributing to the uneven distribution of atherosclerotic lesions. This study investigates the role of Aff3ir-ORF2, a novel nested gene variant, in disturbed flow-induced endothelial cell activation and atherosclerosis.
Published in
Disruption of the novel nested gene Aff3ir mediates disturbed flow-induced atherosclerosis in mice
He S, Huang L, Chen Z et al. · eLife 2025 · PMID 40315012 · doi:10.7554/eLife.103413
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Also filed as BioProject PRJNA1208120 and SRA study SRP556132. Searching any of these in the dataset finder brings you back here.

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