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Effect of cyclic strain in neurons isolated from dorsal root ganglia

GSE286272 Mus musculus (mouse) RNA-seq (gene expression) 18 samples Submitted 2025/01/31 Platform GPL34328
At a glance

RNA-seq (gene expression) · mouse · 18 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
18 samples: 6 × Control sample, no cyclic stimulation, vs 6 × Compressed sample, cyclic stimulation, 5% strain, 20 cycles, 6 hours post-stimulation, vs 6 × Compressed sample, cyclic stimulation, 5% strain, 20 cycles, 24 hours post-stimulation,Groups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Molecular resilience of neurons to repetitive mechanical compressionCommunications biology · 2026
Summary (written by the submitters)
Organs and cells in our body are continuously exposed to mechanical forces. Neurons, in particular, encounter mechanical stimuli during neurodevelopment, aging, pathological conditions, and routine functions such as homeostatic processes and movement. How do cells, which endure mechanical stress on a daily basis, withstand these forces and remain functional throughout our long lifespans?
Read the full summary ↓
To maintain their functionality, cells must have evolved self-repair mechanisms that allow them to tolerate stress and repair damage up to a manageable threshold. This study aims to explore the relationship between damage and repair mechanisms that are crucial for preserving the structural and functional integrity of axons over time. Dorsal Root Ganglia neurons are used as a model system, as they are particularly relevant due to their exposure to daily mechanical movements. An experimental setup has been developed to apply repeated cycles of compression to neurons grown on an elastic substrate. Understanding how neurons respond to mechanical strain and sustain homeostasis will not only deepen our knowledge of the effects of mechanical stress on neurons but also provide valuable insights into restoring cellular functions.
Published in
Molecular resilience of neurons to repetitive mechanical compression
Coppini A, Cappello V, Nasrin SR et al. · Communications biology 2026 · PMID 41845043 · doi:10.1038/s42003-026-09661-4
This dataset
Open GSE286272 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE286272_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1208509 and SRA study SRP556297. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41845043) ↗
Study design
6 × Control sample, no cyclic stimulation, vs 6 × Compressed sample, cyclic stimulation, 5% strain, 20 cycles, 6 hours post-stimulation, vs 6 × Compressed sample, cyclic stimulation, 5% strain, 20 cycles, 24 hours post-stimulation,

Supports a between-group comparison across 18 samples.

How we read this: 3 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
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