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Gene expression profile of mouse diabetic kidney disease (DKD) injury

GSE287026 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/09/11 Platform GPL24247
Summary
Diabetic kidney disease (DKD) is a significant clinical challenge, with an increasing prevalence. Our research identified that fibroblast growth factor 4 (FGF4) secreted by podocytes is a key factor in a mouse model of DKD. Given the importance of FGF4 in DKD-induced kidney injury, we performed gene expression analysis on kidney tissues. This analysis compared db/db model mice with those treated with recombinant FGF4 (rFGF4). The results showed that, compared to the db/db model group, db/db mice treated with long-term rFGF4 demonstrated significant improvements in renal function markers, such as serum urea nitrogen and urinary protein levels.Overall, our findings indicate that FGF4 is a critical regulatory factor in DKD-induced renal injury, providing evidence that it alleviates glomerular damage by inhibiting oxidative stress and apoptosis.
Published in
FGF4-FGFR1 signaling promotes podocyte survival and glomerular function to ameliorate diabetic kidney disease in male mice
Zhou J, Wang S, Lou J et al. · Nature communications 2025 · PMID 41290710 · doi:10.1038/s41467-025-65978-4
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Also filed as BioProject PRJNA1211003 and SRA study SRP557739. Searching any of these in the dataset finder brings you back here.

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