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Junctophilin-2 Regulates Store-Operated Calcium Entry to Drive Cardiac Fibroblast Activation, Fibrotic Repair, and Angiogenesis After Myocardial Infarction

GSE287096 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/06/23 Platform GPL24247
Summary
Calcium homeostasis in cardiac fibroblasts (CFs) are thought to play a critical role in myocardial repair and remodeling following injury. Junctophilin-2 (JP2) is a structural protein known to regulate intracellular calcium signaling and excitation-contraction coupling in cardiomyocytes. However, the role of JP2 in CF biology remains unexplored. To investigate the functional role of JP2 in CFs, we transduced primary CFs with adenoviruses expressing GFP, JP2, or a JP2 targetting shRNA and determined differentially expressed genes via RNA-sequencing. JP2 overepression and silencing had opposite effects on the expression of genes associated with fibrosis, migration, and cell division.
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Junctophilin-2 Regulates Store-Operated Calcium Entry to Drive Cardiac Fibroblast Activation, Fibrotic Repair, and Angiogenesis After Myocardial Infarction
Wang J, Yang Bennett DS, Echard EJ et al. · Circulation 2025 · PMID 40709455 · doi:10.1161/CIRCULATIONAHA.125.073937
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Also filed as BioProject PRJNA1211116 and SRA study SRP557656. Searching any of these in the dataset finder brings you back here.

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