KAT6B overexpression rescues embryonic lethality in homozygous null KAT6A mice restoring vitality and normal lifespan [RNA-seq]
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × Kat6a WT Kat6b WT, vs 4 × Kat6a KO Kat6b WT, vs 4 × Kat6a WT Kat6b Tg, vs 4 × Kat6a KO Kat6b Tg,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- KAT6B overexpression rescues embryonic lethality in homozygous null KAT6A mice restoring vitality and normal lifespanNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE287244_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1211682 and SRA study SRP557930. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8742006 Kat6a WT Kat6b WT, rep 1 Kat6a WT Kat6b WT,
- GSM8742007 Kat6a WT Kat6b WT, rep 2 Kat6a WT Kat6b WT,
- GSM8742008 Kat6a WT Kat6b WT, rep 3 Kat6a WT Kat6b WT,
- GSM8742009 Kat6a WT Kat6b WT, rep 4 Kat6a WT Kat6b WT,
- GSM8742010 Kat6a KO Kat6b WT, rep 1 Kat6a KO Kat6b WT,
- GSM8742011 Kat6a KO Kat6b WT, rep 2 Kat6a KO Kat6b WT,
- GSM8742012 Kat6a KO Kat6b WT, rep 3 Kat6a KO Kat6b WT,
- GSM8742013 Kat6a KO Kat6b WT, rep 4 Kat6a KO Kat6b WT,
- GSM8742014 Kat6a WT Kat6b Tg, rep 1 Kat6a WT Kat6b Tg,
- GSM8742015 Kat6a WT Kat6b Tg, rep 2 Kat6a WT Kat6b Tg,
- GSM8742016 Kat6a WT Kat6b Tg, rep 3 Kat6a WT Kat6b Tg,
- GSM8742017 Kat6a WT Kat6b Tg, rep 4 Kat6a WT Kat6b Tg,
- GSM8742018 Kat6a KO Kat6b Tg, rep 1 Kat6a KO Kat6b Tg,
- GSM8742019 Kat6a KO Kat6b Tg, rep 2 Kat6a KO Kat6b Tg,
- GSM8742020 Kat6a KO Kat6b Tg, rep 3 Kat6a KO Kat6b Tg,
- GSM8742021 Kat6a KO Kat6b Tg, rep 4 Kat6a KO Kat6b Tg,
- GSE287243 KAT6B overexpression rescues embryonic lethality in homozygous null KAT6A mice restoring vitality and normal lifespan [CUT&TAG] 20 samples shares kat6b, kat6a, overexpression, homozygous, embryonic, lethality, restoring, vitality
- GSE318436 Effects of histone acetyltransferase dead mutation of KAT6A and KAT6B on gene expression in E9.5 mouse embryos and E14.5 mouse foetal liver hematopoietic cells 40 samples shares kat6b, kat6a
- GSE250570 RNA-seq analysis of neuronal differentiation of KAT6A/B knockout mouse embryonic stem cells 48 samples shares kat6a, embryonic
- GSE224275 Effects on the transcriptome of mouse embryonic fibroblasts after both Son overexpression and knockdown and treatment with 3μM nintedanib, 1μM ponatinib, 3μM proflavine hemisulfate, and 1μM pyrvinium pamoate 43 samples shares overexpression, embryonic
- GSE232844 Effect of conditional triple-knockout of Jmjd2a/Kdm4a, Jmjd2b/Kdm4b and Jmjd2c/Kdm4c or overexpression of KDM4C/JMJD2C mutants with different phase separation ability on gene expression in mouse embryonic stem cells. [RNA-Seq] 10 samples shares overexpression, embryonic
- GSE271800 Diploid embryo complementation of embryonic stem cells efficiently generates a homozygous Gjb2 mutant deaf mouse model 131 samples shares homozygous, embryonic
- GSE232845 Effect of conditional triple-knockout of Jmjd2a/Kdm4a, Jmjd2b/Kdm4b and Jmjd2c/Kdm4c or overexpression of KDM4C/JMJD2C mutants with different phase separation ability on gene expression in mouse embryonic stem cells. [ChIP-Seq] 46 samples shares overexpression, embryonic
- GSE217780 Fosl2 overexpression and Ezh2 inhibition in mouse embryonic fibroblasts 15 samples shares overexpression, embryonic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.