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Transcriptome profiling of kidney medulla of Actr3 KO mice

GSE287609 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/10/16 Platform GPL21103
Summary
Renal tubule-specific Actr3 knockout mice (Actr3-fl/fl*Cdh16-Cre) were generated. Transcriptome profiling (RNA-Seq) and differential gene expression analysis of isolated renal medulla from KO and WT mice at p14 was performed. Actr3 KO mice showed transcriptional changes associated with Actr3 loss and kidney disease.
Published in
Arp2/3-dependent regulation of ciliogenesis governs adaptive distal tubular epithelial cell states in kidney disease
Rogg M, Weißer L, Maier JI et al. · Science advances 2025 · PMID 41313769 · doi:10.1126/sciadv.ady1623
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Also filed as BioProject PRJNA1213819 and SRA study SRP558796. Searching any of these in the dataset finder brings you back here.

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