GEO series
Neuronal conversion of pre-labeled astrocyte using adeno-asociated viruses in vivo
GSE288733
Mus musculus
Expression profiling by high throughput sequencing
18 samples
2025/11/09
GPL24247
Summary
Neuronal reprogramming using adeno-associated viruses (AAVs) carrying a GFAP mini-promoter to drive neurogenic transcription factor expression in astrocytes in vivo were refuted due to off-target neuronal expression. Here, we show successful neuronal conversion of pre-labeled astrocytes using AAV-GFAP to express phospho-deficient Ascl1SA6, and demonstrate that miR124 target sites reduce off-target neuronal expression. Finally, single cell transcriptomic and pseudotime trajectory analyses confirmed Ascl1SA6-driven astrocyte-to-neuron conversion, and more limited oligodendrocyte conversion events
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Paper (PMID 41350397) ↗
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