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TGFβ maintains smooth muscle cell contractile phenotype via PDK4-dpendent regulation of Ac-CoA production [ATAC-Seq_TGF-siPDK4]

GSE288977 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2025/09/01 Platform GPL18573
Summary
We find that TGFβ signaling in SMCs induced ACSS2-dependent production of Ac-CoA in a PDK4-dependent manner. TGFb induces SMC contractile phenotype and glycolysis.
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Also filed as BioProject PRJNA1220143 and SRA study SRP562055. Searching any of these in the dataset finder brings you back here.

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