ID8 cells manifest phenotypic plasticity and molecular heterogeneity of high-grade serous ovarian cancer in response to the local tissue niche
RNA-seq (gene expression) · mouse · 17 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 17 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ID8 cells manifest phenotypic plasticity and molecular heterogeneity of high-grade serous ovarian cancer in response to the local tissue nicheScientific reports · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE289286_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1222341 and SRA study SRP563223. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 5 replicated groups read from 17 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8788393 ID8 cell line
- GSM8788394 ID8 ortho1 ID8 ortho
- GSM8788395 ID8 ortho2 ID8 ortho
- GSM8788396 ID8 ortho3 ID8 ortho
- GSM8788397 ID8 asc T1.1 ID8 asc T1
- GSM8788398 ID8 asc T1.2 ID8 asc T1
- GSM8788399 ID8 asc T1.3 ID8 asc T1
- GSM8788400 ID8 asc T2.1 ID8 asc T2
- GSM8788401 ID8 asc T2.2 ID8 asc T2
- GSM8788402 ID8 asc T2.3 ID8 asc T2
- GSM8788403 ID8 Met Int 1 ID8 Met Int
- GSM8788404 ID8 Met Int 2 ID8 Met Int
- GSM8788405 ID8 Met Int 3 ID8 Met Int
- GSM8788406 C57BL6 OVARY
- GSM8788407 C57BL6 INTESTINE
- GSM8788408 ID8 sc 2 ID8 sc
- GSM8788409 ID8 sc 3 ID8 sc
- GSE249062 Effect of SMARCA4 degradation on ID8 ovarian cancer cells senescent and not senescent. 24 samples shares id8, ovarian
- GSE302064 Transcriptome analysis of the effect of RAD52 knockout on olaparib response in BRCA2-deficient, olaparib-resistant murine ovarian cancer cells (ID8-OR) 12 samples shares id8, ovarian
- GSE263461 Single cell RNA sequencing of ID8 mouse ovarian tumor samples with genetic pertrubation of cytokine signaling 10 samples shares id8, ovarian
- GSE237954 Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer 122 samples shares phenotypic, plasticity
- GSE239479 AP-3-84 effects on gene expression in thioglycollate-induced, ID8 ascites or bone-marrow derived macrophages 48 samples shares id8
- GSE294832 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part10] 1000 samples shares phenotypic
- GSE294911 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part14] 1000 samples shares phenotypic
- GSE294535 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice[part5] 1000 samples shares phenotypic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.